A three-year-old boy has become the first patient in the world to be cured of a potentially fatal illness with a biodegradable implant made to the patient’s exact specifications by 3D printing technology, doctors have said. The boy was one of three babies in the United States who underwent pioneering emergency surgery involving the insertion of 3D printed splints into their throats. These were designed to keep their windpipes open while allowing the infants to grow normally.

The first operation was on Kaiba Gionfriddo from Ohio in 2012 when he was just three months old and suffering from tracheobronchomalacia, which affects about 1 in 2,000 babies and causes the windpipe to collapse periodically, preventing normal breathing and leading to profound health complications and premature death. Scientists announced that all three boys have responded well to the treatment, with Kaiba now deemed to be effectively cured. His biodegradable implant has been partially re-absorbed by his body meaning that he no longer has to rely on it completely for breathing.

“We report that this engineering design has worked as intended and that the first [patient] to receive this implant three years ago appears to be cured of tracheobronchomalacia with the splint hat has not functionally degraded,” said Glen Green, who was part of the operation team at the C S Mott Children’s Hospital at the University of Michigan in Ann Arbor.

The implants were made from a non-toxic, degradable polymer printed layer by layer into its final three-dimensional shape based on information gathered directly from CT scans of each baby’s windpipe. The scientists fine-tuned the printing instructions for each device to suit the individual needs of each baby boy.

“These cases broke new ground for us because we were able to use 3D printing to design a device that successfully restored patients’ breathing through a procedure that had never been done before,” Dr Green said.

“Before this procedure, babies with severe tracheobronchomalacia had little chance of surviving. Today, our first patient Kaiba is an active, healthy 3-year-old in preschool with a bright future. The device worked better than we could have ever imagined,” he said.

April Gionfriddo, Kaiba’s mother, said: “The first time he was hospitalised, doctors told us he many not make it out. It was scary knowing he was the first child to ever have this procedure, but it was or only choice and it saved his life."

The two other baby boys received their implants at the ages of 5 months and 16 months and, like Kaiba, they are now free of the normal restrictions patients have to live with, such as being treated with powerful drugs and placed on mechanical ventilators, according to the study in the journal Science Translational Medicine.